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Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and …
May 5, 2022 · Here, we describe the identification and comprehensive validation of acriflavine as a potent and highly specific inhibitor of the SARS-CoV-2 papain-like protease (PL pro). The …
Ncbi.nlm.nih.govAcriflavine, a clinically approved drug, inhibits SARS-CoV-2
May 19, 2022 · Using high-throughput screening, we identify acriflavine (ACF) as a potent papain-like protease (PL pro) inhibitor. NMR titrations and a co-crystal structure confirm that …
Pubmed.ncbi.nlm.nih.govAcriflavine - Wikipedia
Acriflavine (INN: acriflavinium chloride) is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of com…
En.wikipedia.org(PDF) Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 …
Mar 21, 2021 · The identification of acriflavine as an active papain-like protease inhibitor for countering COVID-19 caused by SARS-CoV-2 is promising and essential in the sense that it …
Researchgate.netAcriflavine, a clinically aproved drug, inhibits SARS-CoV-2
Mar 20, 2021 · Here, we discovered acriflavine (ACF) as an effective inhibitor of SARS-CoV-2. Acriflavine (ACF) is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride. and …
Biorxiv.orgAcriflavine, a clinically aproved drug, inhibits SARS-CoV-2
Mar 21, 2021 · Using high-throughput screening, we identified acriflavine as a potent papain-like protease (PL pro) inhibitor. NMR titrations and a co-crystal structure confirm that acriflavine …
Biorxiv.orgResearchers examine acriflavine's antiviral potential …
Mar 24, 2021 · Two molecules of dechlorinated acriflavine (proflavine) are able to stack within the binding pocket of PL PRO, inducing a large conformational change characterized by rotation and translocation
News-medical.netZirconium-Based Metal–Organic Frameworks as …
Using high-throughput screening, we identify acriflavine (ACF) as a potent papain-like protease (PLpro) inhibitor. NMR titrns. and a co-crystal structure confirm that acriflavine blocks the PLpro catalytic pocket in an unexpected …
Pubs.acs.orgAcriflavine, an Acridine Derivative for Biomedical …
Aug 26, 2022 · Acriflavine (ACF) has been suggested to inhibit HIF1, but its mechanism of action is unknown. Here we investigated the interaction of ACF with DNA and long non-coding RNAs (lncRNAs) and its function in human …
Pubs.acs.orgIs acriflavine an efficient co-drug in chemotherapy? - PMC
Jul 7, 2023 · Acriflavine (ACF) has been recognized as the most potent HIF-1 inhibitor in anti-cancer therapy among the 336 drugs approved by the Food and Drug Administration. 14 ACF …
Ncbi.nlm.nih.gov(PDF) Acriflavine, an Acridine Derivative for …
Aug 26, 2022 · Acriflavine (ACF) has been known for years as an antibacterial drug. The identification of key oncogenic mechanisms has brought, in recent years, a significant increase in studies on ACF as a
Researchgate.netHIF-1α- Targeting Acriflavine Provides Long Term Survival and
Nov 2, 2017 · Acriflavine (ACF) decreases downstream genes of HIF-1s in brain cancer cells. Acriflavine significantly reduces PGK-1 and VEGF mRNA expression induced by hypoxia …
Nature.comAcriflavine, a clinically approved drug, inhibits SARS-CoV-2 and …
Napolitano et al. discovered acriflavine (ACF), a clinically approved drug, as an effective inhibitor of SARS-CoV-2 papain-like protease (PLpro). ACF inhibits viral replication at nanomolar …
Cell.comAcriflavine - an overview | ScienceDirect Topics
Acriflavine, a mixture of trypaflavin (3,6-diamino-10-methylacridinium chloride) and proflavine (3,6-diaminoacridine), is a fluorescent drug. In a xenograft tumor model, acriflavine was found …
Sciencedirect.comAcriflavine: Uses, Interactions, Mechanism of Action - DrugBank …
Acriflavine is a topical antiseptic indicated in the treatment of infected wounds and for skin disinfection.
Go.drugbank.comIs acriflavine an efficient co-drug in chemotherapy?
Jul 17, 2023 · The results of the uptake study showed significantly more efficient cellular uptake of acriflavine than doxorubicin, whether administered alone or in combination with an …
Pubs.rsc.orgAcriflavine, a clinically approved drug, inhibits SARS-CoV - Cell …
Napolitano et al. discovered acriflavine (ACF), a clinically approved drug, as an effective inhibitor of SARS-CoV-2 papain-like protease (PLpro). ACF inhibits viral replication at nanomolar …
Cell.com