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Amyotrophic lateral sclerosis - BMJ Best Practice
Sep 27, 2024 · Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness that can start in limb, axial, bulbar, or respiratory muscles and then generalises relentlessly, causing progressive disability and ultimately death, usually from respiratory failure. ALS is the most common form of motor neuron
Bestpractice.bmj.com肌萎缩侧索硬化 - 症状、诊断和治疗 | BMJ Best Practice
Sep 19, 2024 · 肌萎缩侧索硬化（amyotrophic lateral sclerosis, ALS）是一种以皮质、脑干和脊髓腹侧运动神经元变性为特征的进行性疾病。 ALS 通常表现为上运动神经元和下运动神经元同时受累的症状和体征，最初累及神经轴的 1 个节段（即，颅部、颈部、胸部或腰骶部），随后通常进行性扩展至邻近区域。
Bestpractice.bmj.comAssessment of metabolic alkalosis - BMJ Best Practice
Jul 29, 2021 · Definition. Metabolic alkalosis is indicated by an increase in plasma bicarbonate (HCO3) level. Arterial pH >7.45 defines alkalosis. It is the consequence of disorders that cause either a loss of hydrogen ions from the body or an increase in plasma HCO3. The severity of alkalosis depends on the severity of underlying disorder; it may be more
Bestpractice.bmj.comProgressive supranuclear palsy - BMJ Best Practice
May 16, 2024 · Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that classically presents with oculomotor dysfunction (abnormal vertical eye movements), postural instability and falls, parkinsonism, and cognitive (mainly executive) dysfunction. PSP is the most frequent parkinsonian disorder after idiopathic Parkinson’s disease and has a
Bestpractice.bmj.comStatus epilepticus - Symptoms, diagnosis and treatment - BMJ …
Dec 16, 2022 · Status epilepticus (SE) is a life-threatening neurological condition defined as 5 or more minutes of either continuous seizure activity or repetitive seizures without regaining consciousness. Generalised convulsive SE in both its subtle and overt sub-types constitutes the most frequent variant. Diagnosis of non-convulsive SE can be difficult
Bestpractice.bmj.comSymptoms, diagnosis and treatment - BMJ Best Practice
Dec 5, 2023 · Salmonellosis is a very common cause of gastroenteritis in the developed world and invasive disease in the developing world. Salmonella enterica causes both sporadic infections and outbreaks of disease. Almost any food product can be contaminated, but outbreaks are most commonly due to poultry, dairy items such as raw milk, and undercooked eggs.
Bestpractice.bmj.comDifferential diagnosis of symptoms - BMJ Best Practice
Jan 10, 2024 · Urine total protein: ≥3.5 g/day. The presence of nephrotic-range proteinuria with edema, hypoalbuminemia (<3.0 g/dL), and hyperlipidemia is defined as nephrotic syndrome. Glomerular proteinuria. Urine total protein: 1-20 g/day. Passage of protein from glomerular capillary blood (mainly albumin) into the urine. Tubular proteinuria.
Bestpractice.bmj.comMononeuritis multiplex - Symptoms, diagnosis and treatment
Sep 26, 2023 · Mononeuritis multiplex (MNM) consists of a heterogeneous group of peripheral nerve disorders. MNM presents with sensory and motor deficits in the distribution of specific peripheral nerves, and may be acute, subacute, or (rarely) chronic. MNM is most commonly caused by vasculitis, which may be either systemic or isolated to the nerves.
Bestpractice.bmj.comSymptoms, diagnosis and treatment - BMJ Best Practice
May 23, 2023 · Definition. Aortic dissection describes the condition when a separation has occurred in aortic wall intima, causing blood flow into a new false channel composed of the inner and outer layers of the media. Dissection most commonly occurs with a discrete intimal tear, but can occur without one. Type A dissection involves the ascending aorta, with
Bestpractice.bmj.comSustained ventricular tachycardias - BMJ Best Practice
Feb 23, 2024 · Sustained VT is a ventricular rhythm faster than 100 bpm typically lasting at least 30 seconds or requiring termination earlier due to haemodynamic instability. VT is defined as a wide complex tachycardia (QRS 120 milliseconds or greater) that originates from one of the ventricles, and is not due to aberrant conduction (e.g., from bundle branch
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