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Serine and one-carbon metabolism in cancer - Nature
WEBSep 16, 2016 · serine is a non-essential amino acid that can be taken up by the cell or synthesized de novo from glycolytic intermediates through the serine synthesis pathway (SSP). serine is used for many
Nature.comSerine hydroxymethyltransferase as a potential target of …
WEBJun 23, 2022 · serine hydroxymethyltransferase (SHMT) produces 5,10-methylenetetrahydrofolate (CH2-THF) from tetrahydrofolate with serine to glycine conversion. SHMT is a potential drug target in parasites
Nature.comPHGDH: a novel therapeutic target in cancer - Nature
WEBJul 1, 2024 · serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that
Nature.comHydrogen sulfide and polysulfides induce GABA/glutamate/d …
WEBOct 31, 2023 · The release of d-serine, l-serine, and glutamine induced by H 2 S and H 2 S 2 was not concentration–dependent and less efficient than that of GABA, glutamate, and glycine (Figs. 3, 4), probably
Nature.comThe ins and outs of serine and glycine metabolism in cancer
WEBJan 28, 2021 · The resulting elevated synthesis of serine and glycine has been shown to lead to increased availability of methyl donor SAM, and subsequently to increased DNA methylation 61. Additionally, loss of
Nature.comMycobacterium tuberculosis produces d-serine under hypoxia to …
WEBMay 28, 2024 · Hypoxia induces d-serine production by Mtb. To determine the metabolic responses of Mycobacteria to hypoxia, virulent Mtb H37Rv was cultured under hypoxic conditions using Wayne’s in vitro
Nature.comKdpD is a tandem serine histidine kinase that controls K - Nature
WEBApr 15, 2024 · KdpD is known as the sensory histidine kinase of two-component system KdpDE that controls the transcription of the kdpFABC genes. Here, the authors show that KdpD acts as atypical serine kinase
Nature.comSerine synthesis through PHGDH coordinates nucleotide levels …
WEBDec 21, 2018 · The serine, glycine, one-carbon network generates carbon units that satisfy many metabolic demands including nucleotide precursors for anabolic metabolism, redox maintenance, and substrates for
Nature.comInsulin-regulated serine and lipid metabolism drive peripheral
WEBJan 25, 2023 · serine and glycine restriction is widely used to modulate health outcomes in mice and is relatively well-tolerated for several months 16,19,20,21,22.To model the effect of systemic serine
Nature.comDesign strategy for serine hydroxymethyltransferase probes …
WEBFeb 20, 2019 · serine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reaction that converts serine to glycine. It plays an important role in one-carbon metabolism. Recently, SHMT has been shown
Nature.com