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Zhihu.com什么是雷帕霉素?作用原理和应用方向是什么? - 知乎
WEB雷帕霉素的作用原理是:抑制细胞的TOR复合体。. TOR全名Target of rapamycin(雷帕霉素靶蛋白),是一种信号分子,负责调控所有真核生物的每个细胞生长。. TOR是在雷帕霉素之后发现的,1991年,M. N. Hall教授课题组的J. Heightman从耐雷帕霉素的酵母菌中鉴定出了TOR基因
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Zhihu.com雷帕霉素(Rapamycin)的丙酮溶液稳定性如何? - 知乎
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Zhihu.com【求助】请教有关rapamycin诱导自噬研究的一些初级问题
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WEBrapamycin (Sirolimus) is a new type of macrolide anti-rejection drug, is currently the world's latest powerful immunosuppressant rapamycin is currently mainly used for anti-rejection after organ transplantation, in addition to heart stents.
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WEB1.靶点机制 经典信号通路 PAM,即磷脂酰肌醇 3-激酶(phosphoinositide 3-kinase,PI3K)-蛋白激酶 B(protein kinase B,AKT)-哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路在多种肿瘤中异常激活,参与调控肿瘤细胞增殖、分化和凋亡等生命过程,也是抗肿瘤药物研发所关注的重要通路。
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