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    WEB知乎,让每一次点击都充满意义 —— 欢迎来到知乎,发现问题背后的世界。

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    什么是雷帕霉素?作用原理和应用方向是什么? - 知乎

    WEB雷帕霉素的作用原理是:抑制细胞的TOR复合体。. TOR全名Target of rapamycin(雷帕霉素靶蛋白),是一种信号分子,负责调控所有真核生物的每个细胞生长。. TOR是在雷帕霉素之后发现的,1991年,M. N. Hall教授课题组的J. Heightman从耐雷帕霉素的酵母菌中鉴定出了TOR基因

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    怎么减少雷帕霉素的副作用但同时达到抗衰老效果? - 知乎

    WEBMay 12, 2022 · 在抗衰老的研究中,激活细胞的自噬活动是其中一个主要的方向。而基于自噬路径延缓衰老,起码有四个方法,其一是通过节食减少卡路里,这是至今研究证据最为充分和安全的抗衰老手段,而二甲双胍(Metformin)激活细胞AMPK信号、亚精胺(Spermidine)抑制EP300的活动,和雷帕霉素(rapamycin)抑制细胞

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    雷帕霉素(Rapamycin)的丙酮溶液稳定性如何? - 知乎

    WEBApr 25, 2019 · 1 个回答. 我的经验是rapa在DMSO中稳定性最好,溶解度也最大,但是室温不稳定。. 丙酮真的没经验,如果可能的话换别的溶剂吧. 雷帕霉素在丙酮溶液中是否会发生变性?. 能否长久保存(保存1-2周)?. 如果可以,如何保存?. 所需温度多少?.

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    【求助】雷帕霉素(rapamycin)处理细胞的使用方法?

    WEB我用rapamycin处理细胞之后总是做不出文献中的结果,考虑两种可能原因。一是,我买的rapamycin有问题,先后买了国产碧云天(说是进口分装但不愿告诉我什么牌子进口的)和CST的,国产的没做出来就买了CST的,但是CST包装只有10nM(9.1UG),太少了包装ep管里根本看不到任何东西,抱一线希望我还是用DMSO

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    雷帕霉素真的能延长寿命?甚至能抗癌么? - 知乎

    WEBAug 31, 2016 · 总之雷帕霉素抗癌是真的,延长哺乳动物寿命(至少小鼠、大鼠)也是真的,至于人类,这两点作用,目前都在热火朝天研究中!. 我们期待更多研究资料的披露,以及雷帕霉素或其衍生物早日造福(如果可以的话)我们的那天吧!. ——TIMEPIE——. “我们不 …

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    【求助】请教有关rapamycin诱导自噬研究的一些初级问题

    WEB准备做一些自噬相关的研究,没有经验,打算用rapamycin诱导,想到一些问题,向有经验的朋友请教,先谢过大家了! rapamycin诱导autophagy时,细胞密度如何为好?

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    雷帕霉素 - 知乎

    WEBrapamycin (Sirolimus) is a new type of macrolide anti-rejection drug, is currently the world's latest powerful immunosuppressant rapamycin is currently mainly used for anti-rejection after organ transplantation, in addition to heart stents.

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    WEB1.靶点机制 经典信号通路 PAM,即磷脂酰肌醇 3-激酶(phosphoinositide 3-kinase,PI3K)-蛋白激酶 B(protein kinase B,AKT)-哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路在多种肿瘤中异常激活,参与调控肿瘤细胞增殖、分化和凋亡等生命过程,也是抗肿瘤药物研发所关注的重要通路。

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