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Related websites

The MYCN Protein in Health and Disease - PMC - National …

Ncbi.nlm.nih.gov

MYCN Gene - GeneCards | MYCN Protein | MYCN Antibody

WEBAug 6, 2024 · mycn (mycn Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with mycn include Feingold Syndrome 1 and Megalencephaly-Polydactyly Syndrome. Among its related pathways are Signaling by Receptor Tyrosine Kinases and Neuroscience.

Genecards.org

MYCN gene - MedlinePlus

WEBThe mycn gene provides instructions for making a protein that plays an important role in the formation of tissues and organs during development before birth. Learn about this gene and related health conditions.

Medlineplus.gov

Molecular Mechanisms of MYCN Dysregulation in Cancers

WEBFeb 3, 2021 · mycn, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis.

Ncbi.nlm.nih.gov

MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and …

WEBSep 12, 2022 · The review highlights how mycn influences the HR-NB scenario and the new therapeutic approaches that are currently proposed to target it, in consideration of mycn as a highly relevant target for HR-NB patient management.

Ncbi.nlm.nih.gov

MYCN drives oncogenesis by cooperating with the histone

WEBMar 28, 2024 · mycn governs a malignant NB cell identity by activating canonical MYC target genes and suppressing neuronal differentiation genes. We systematically investigated mycn biological functions and transcriptional activity in several NB cell lines through both loss and gain of function studies.

Journals.plos.org

Regulation of cancer cell metabolism: oncogenic MYC in the

WEBJul 10, 2020 · The MYC family of oncoproteins, including MYC, MYCL, and mycn, is an essential, master regulator of metabolic reprogramming in a broad spectrum of human cancers. 8,9 While MYC expression is

Nature.com

The MYCN Protein in Health and Disease - PubMed

WEBMar 30, 2017 · mycn is a member of the MYC family of proto-oncogenes. It encodes a transcription factor, mycn, involved in the control of fundamental processes during embryonal development. The mycn protein is situated downstream of several signaling pathways promoting cell growth, proliferation and …

Pubmed.ncbi.nlm.nih.gov

The MYC oncogene — the grand orchestrator of cancer growth

WEBSep 10, 2021 · A novel therapeutic synthetic lethal approach could address the transcription-independent role of mycn in preventing replication stress-induced DNA damage.

Nature.com

Frontiers | Editorial: Molecular Mechanisms and Treatment of …

WEBNov 29, 2021 · mycn encodes a transcription factor that functions as an oncoprotein, similar to other MYC family proteins, c-MYC and L-MYC. Since its discovery as an amplified gene homologous to c-MYC in neuroblastoma, mycn has been found to be amplified and overexpressed in various tumors and promotes aggressiveness. In this special issue, we …

Frontiersin.org