Momelotinib
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Momelotinib - Wikipedia
WEBmomelotinib, sold under the brand name Ojjaara, is an anticancer medication used for the treatment of myelofibrosis. [1] It is a Janus kinase inhibitor and it is taken by mouth. [1] The most common adverse reactions include dizziness, fatigue, bacterial infection, hemorrhage, thrombocytopenia, diarrhea, and nausea. [4]
En.wikipedia.orgMomelotinib Uses, Side Effects & Warnings - Drugs.com
WEBNov 7, 2023 · What is momelotinib? momelotinib is used to treat adults with specific types of myelofibrosis who have anemia. momelotinib may also be used for purposes not listed in this medication guide.
Drugs.comMomelotinib for myelofibrosis: our 14 years of experience with 100
WEBMar 18, 2024 · momelotinib is an ATP-competitive small molecule inhibitor of Janus kinase proteins (JAKi), including JAK1, JAK2, JAK3, and TYK2; its other clinically relevant targets include activin A receptor
Nature.comMomelotinib long-term safety and survival in myelofibrosis: …
WEBJul 14, 2023 · momelotinib is the first inhibitor of Janus kinase 1 (JAK1) and JAK2 shown to also inhibit activin A receptor type 1 (ACVR1), a key regulator of iron homeostasis, and has demonstrated improvements in splenomegaly, constitutional symptoms, and anemia in myelofibrosis (MF).
Ashpublications.orgMomelotinib for the treatment of myelofibrosis | Blood | American
WEB1 day ago · In September 2023, the US Food and Drug Administration approved momelotinib for the treatment of myelofibrosis (MF) with anemia, marking the fourth US regulatory approval of a Janus kinase inhibitor for MF. A positive opinion from the European Medicines Agency followed in November 2023. momelotinib’s ability to address …
Ashpublications.orgMomelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, …
WEBNov 11, 2023 · A fourth JAK inhibitor, momelotinib, is poised for FDA approval soon and has been shown to provide additional benefit in alleviating transfusion-dependent anemia in MF.
Ncbi.nlm.nih.govOjjaara (momelotinib) approved in the US as the first and only
WEBSep 15, 2023 · GSK plc (LSE/NYSE: GSK) today announced that the US Food and Drug Administration (FDA) has approved Ojjaara (momelotinib) for the treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis or secondary myelofibrosis (post-polycythemia vera and post-essential thrombocythemia), in adults with anemia.
Us.gsk.comMomelotinib: an emerging treatment for myelofibrosis patients …
WEBJan 19, 2022 · momelotinib is one of the prime candidates to durably address the critical unmet needs of MF patients with moderate/severe anemia. Importantly, momelotinib may have overall survival benefits in frontline and second-line MF patients.
Jhoonline.biomedcentral.comOmjjara | European Medicines Agency (EMA)
WEBNov 10, 2023 · By blocking JAKs, momelotinib reduces the inflammation resulting from abnormal production of blood cells which relieves splenomegaly and symptoms caused by myelofibrosis.
Ema.europa.euOjjaara (momelotinib) approved in the US as the first and only
WEBSep 15, 2023 · GSK plc (LSE/NYSE: GSK) today announced that the US Food and Drug Administration (FDA) has approved Ojjaara (momelotinib) for the treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis or secondary myelofibrosis (post-polycythaemia vera and post-essential thrombocythaemia), in adults with anaemia. …
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