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Pathology Outlines - Merkel cell carcinoma
merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions. There is emerging evidence of distinct Merkel cell
Pathologyoutlines.comPathology Outlines - Basal cell carcinoma
Dec 15, 2020 · 8090/3 - Basal cell carcinoma, NOS 8097/3 - Nodular basal cell carcinoma 8091/3 - Superficial basal cell carcinoma 8097/3 - Micronodular basal cell carcinoma 8092/3 - Infiltrating basal cell carcinoma 8092/3 - Morpheaform basal cell carcinoma 8094/3 - Basosquamous carcinoma 8090/3 - Pigmented basal cell carcinoma
Pathologyoutlines.comPathology Outlines - Trichoepithelioma / trichoblastoma
Jun 7, 2021 · CK20 positive Merkel cell retention is more common in benign follicular tumors versus basal cell carcinoma, although is not specific (Arch Pathol Lab Med 2017;141:1490) This staining pattern should be interpreted with caution as CK20 positive Merkel cells may be only focally represented and may not be apparent without multiple sections
Pathologyoutlines.comSquamous cell carcinoma
Apr 10, 2023 · Clear cell squamous cell carcinoma: > 25% cells with cytoplasmic clearing (glycogen accumulation or hydropic degeneration) High risk histologic variants Acantholytic: squamous cell carcinoma with acantholysis, pseudoglandular ( CEA negative) ( J Cutan Pathol 2022;49:133 , J Clin Pathol 2006;59:1206 , Dermatol Surg 2011;37:353 )
Pathologyoutlines.comPathology Outlines - Cytokeratin 7 (CK7, K7)
CK7+/c-Kit+/Hale’s Colloidal Iron+. Board review style answer #3. D. Classically, chromophobe renal cell carcinoma would be positive for CK7, c-Kit (or CD117) and Hale’s colloidal iron. Oncocytoma may demonstrate scattered CK7 positivity while conventional clear cell RCC is usually CK7 negative.
Pathologyoutlines.comPathology Outlines - Skin nonmelanocytic tumor
Nail tumors: normal nail grossing (pending) normal nail histology (pending) onychocytic carcinoma (pending) onychocytic matricoma (pending) onychomatricoma (pending) onychopapilloma (pending) subungual exostosis superficial acral fibromyxoma. Other tumors of skin: benign (mature) cystic teratoma Borst-Jadassohn phenomenon connective tissue
Pathologyoutlines.comPathology Outlines - Squamous cell carcinoma
Mar 14, 2023 · Microscopic (histologic) description. Resembles squamous cell carcinoma as seen elsewhere in body. Tumors often display multiple morphologic patterns, calling into question the utility of subdividing the entity. May be keratinizing (usually below the dentate line) or nonkeratinizing (anywhere, although tumors above the dentate line are usually
Pathologyoutlines.comMelanomas with unusual features (balloon cell, verrucous, signet …
Feb 29, 2024 · 2 variants: small cells, so called non-Merkel tumor-like cell variant and large cells, Merkel cell tumor-like variant (Dermatopathology (Basel) 2019;6:231) Small or barely visible cytoplasm with hyperchromatic nucleus with coarse chromatin Cells are atypical and mitoses are easily found No maturation as the lesion goes deeper Monotonous cells
Pathologyoutlines.comPathology Outlines - PAX5
Apr 18, 2022 · Pathophysiology. Encoded by PAX5 at 9q13. Paired box transcription factors have a novel, highly conserved DNA binding motif and regulate early tissue development. Activates B cell specific genes and represses genes specific for other hematopoietic lineages (Oncogene 2012;31:966) Regulates distinct target genes in early and late B cell
Pathologyoutlines.comPathology Outlines - Syringocystadenoma papilliferum
Mar 10, 2022 · Although benign, co-occurrence of basal cell carcinoma, verrucous carcinoma metastatic adenocarcinoma and ductal carcinoma may be observed (Onco Targets Ther 2013;6:233, OrphaNet: Syringocystadenoma Papilliferum [Accessed 5 November 2021])
Pathologyoutlines.com