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IC50 - Wikipedia
WEBEC 50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo. [1] IC 50 can be determined with functional assays or with competition binding assays. Sometimes, IC 50 values are converted to the pic50 scale.
En.wikipedia.org50% of what? How exactly are IC50 and EC50 defined?
WEBThe concepts of ic50 and EC50 are fundamental to pharmacology. The EC50 is the concentration of a drug that gives half-maximal response. The ic50 is the concentration of an inhibitor where the response (or binding) is reduced by half.
Graphpad.comDetermination of half-maximal inhibitory concentration using - PubMed
WEBSep 1, 2016 · Half-maximal inhibitory concentration (ic50) is the most widely used and informative measure of a drug's efficacy. It indicates how much drug is needed to inhibit a biological process by half, thus providing a measure of potency of an antagonist drug in pharmacological research.
Pubmed.ncbi.nlm.nih.govThe IC(50) concept revisited - PubMed
WEBSince the concept of the half maximal inhibitory concentration (IC (50)) is used extensively for studying reversible inhibition enzymatic reactions, it is important to clearly understand the experimental design and the mathematical modeling techniques used to generate IC (50) values.
Pubmed.ncbi.nlm.nih.govIC50 - an overview | ScienceDirect Topics
WEBic50. ic50 refers to the concentration of a compound that inhibits 50% of a specific biological activity or response. AI generated definition based on: Basic Principles of Drug Discovery and Development (Second Edition), 2021
Sciencedirect.comIC50 - an overview | ScienceDirect Topics
WEBic50. The ic50 is a quantitative measure that determines how much of a ligand is needed to inhibit a given biological component by 50%. From: Contraception, 2024
Sciencedirect.comIC50 - an overview | ScienceDirect Topics
WEBThe ic50, derived from the MTT and other such assays, is an important first step in the detection of inhibitory activity against tumour cells. Would the anticancer drugs presently used in the clinic be detected by these assays?
Sciencedirect.comWhen Does the IC50 Accurately Assess the Blocking Potency of …
WEBMar 3, 2020 · Here, we attempt to shed light on the relevance of the IC 50 as an indicator of the IKr blocking potency of a compound and to improve the characterization of its blocking effects using a highly detailed Markov model considering a wide range of …
Ncbi.nlm.nih.govGuidelines for accurate EC50/IC50 estimation - PubMed
WEBThe relative EC50/ic50 is the parameter c in the 4-parameter logistic model and is the concentration corresponding to a respon … This article provides minimum requirements for having confidence in the accuracy of EC50/ic50 estimates.
Pubmed.ncbi.nlm.nih.govCanadian Society of Pharmacology and Therapeutics (CSPT) - IC50
WEBic50 is the concentration of the competitive antagonist required to reduce the activity/binding of an agonist to a specific enzyme, receptor or transporter by 50%.
Pharmacologycanada.org