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Anakinra treatment in critically ill COVID-19 patients: a …
Dec 10, 2020 · anakinra, a recombinant interleukin-1 receptor antagonist, is known to be effective in several hyperinflammatory diseases. We investigated the effects of anakinra on inflammatory parameters and clinical outcomes in critically ill, mechanically ventilated COVID-19 patients with clinical features of hyperinflammation.
Ccforum.biomedcentral.comFast recovery of cardiac function in PIMS-TS patients early using
Apr 7, 2021 · Plasma levels of a C-reactive protein, b procalcitonin, c white blood cell counts, d ferritin, and e body temperature on day of admission to the intensive care unit (ICU), start of anakinra therapy, and until 8 days following cessation of anakinra. Results of 13 anakinra-treated patients of which data were available on multiple days after cessation of anakinra treatment …
Ccforum.biomedcentral.comAnakinra: a silver lining in COVID-19? - Critical Care
Oct 6, 2020 · anakinra (IL-1α and IL-1β blocker) has shown greatly reduced mortality, need for invasive mechanical ventilation, and bettering oxygenation status in severe COVID-19 patients in smaller clinical studies . Hence, anakinra might be effective in managing the severe pandemic state; more so, it is a well-tolerated molecule with no adverse effects.
Ccforum.biomedcentral.comTransitions of blood immune endotypes and improved outcome …
Mar 12, 2024 · Background Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human interleukin 1 receptor antagonist) in participants in the SAVE-MORE trial. Methods Adult patients hospitalized with radiological findings of PCR …
Ccforum.biomedcentral.comTargeting the host response in sepsis: current approaches and …
Dec 6, 2023 · anakinra treatment provided higher odds for clinical improvement and lowered the 28-day mortality from 6.9 to 3.2%. SuPAR and MAS features illustrate the biological and clinical consequences of hyperinflammation such as coagulopathy and tissue damage . The results of the above studies therefore suggest that these classes of biomarkers may
Ccforum.biomedcentral.comTowards personalized medicine: a scoping review of …
May 28, 2024 · One of the RCTs studying anakinra in 696 sepsis patients, failed to demonstrate a mortality reduction, however in a post-hoc analysis treatment with anakinra provided a 30% decrease of 28-day mortality in patients who, at the start of treatment, had both liver dysfunction and disseminated intravascular coagulation which were interpreted by the authors as traits of …
Ccforum.biomedcentral.comToxicities, intensive care management, and outcome of chimeric …
Mar 5, 2024 · IEC-HS management involves anakinra with or without corticosteroids. There are also concerns regarding potential adverse effects of corticosteroid therapy on CAR-T cell function and persistence, but most data suggest that short-term corticosteroids can be employed in the treatment of complications (including CRS/ICANS/IEC-HS) without a clear increase in the …
Ccforum.biomedcentral.comInfluence of therapeutic plasma exchange treatment on short-term
Jan 4, 2024 · Introduction The impact of therapeutic plasma exchange (TPE) on short-term mortality in adult patients with sepsis-induced organ dysfunction remains uncertain. The objective of the study is to assess the effect of adjunct TPE in this setting through a comprehensive literature review. Methods The National Library of Medicine’s Medline, Ovid (Embase), the …
Ccforum.biomedcentral.comBlocking IL-1 to prevent respiratory failure in COVID-19
Jul 18, 2020 · In addition, anakinra will decrease IL-6 production since IL-1 is a potent inducer of IL-6, and thus, the suggested beneficial effects of tocilizumab are likely to be seen also in anakinra. anakinra will not only block IL-1β but also IL-1α which is released due to epithelial and endothelial damage and, in this way, targets the tissue-driven inflammatory response.
Ccforum.biomedcentral.comDiagnostic and management of life-threatening Adult-Onset Still …
Apr 11, 2018 · Background Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. Methods A multicenter case series of intensive care …
Ccforum.biomedcentral.com