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Salicylate poisoning - Symptoms, diagnosis and treatment | BMJ …
WEBAug 21, 2024 · salicylate poisoning after ingestion of ≥125 mg/kg salicylate, ingestion of any amount of methyl salicylate, or, rarely, topical exposure is potentially fatal. Patients can present acutely after accidental or intentional overdose. Chronic exposure to too much salicylate is an important, but difficult, diagnosis.
Bestpractice.bmj.comSalicylate poisoning - Symptoms, diagnosis and treatment | BMJ …
WEBMar 22, 2024 · salicylate poisoning is the result of ingestion of, or (rarely) topical exposure to, chemicals metabolised to salicylate. [1] . Poisoning may occur because of acute or chronic salicylate exposure and is characterised by acid-base disturbances, electrolyte abnormalities, and central nervous system effects. [1] .
Bestpractice.bmj.comSalicylate poisoning - References | BMJ Best Practice
WEBsalicylate poisoning after ingestion of ≥125 mg/kg salicylate, ingestion of any amount of methyl salicylate, or, rarely, topical exposure is potentially fatal. Patients can present acutely after accidental or intentional overdose. Chronic exposure to too much salicylate is an important, but difficul.
Bestpractice.bmj.comParacetamol overdose in adults - BMJ Best Practice
WEBOct 3, 2023 · Staggered overdose: excessive amounts of paracetamol ingested over longer than 1 hour; usually in the context of self-harm. Therapeutic excess: Excessive paracetamol taken with intent to treat pain or fever and without self-harm intent. Paracetamol ingested at a dose greater than the licensed daily dose AND ≥75 mg/kg/24 hours.
Bestpractice.bmj.comAssessment of metabolic acidosis - BMJ Best Practice
WEBJul 19, 2022 · Arterial pH <7.35 defines acidosis. Metabolic acidosis is indicated by a decrease in the plasma bicarbonate level and/or a marked increase in the serum anion gap (AG). Metabolic acidosis may occur due to the following reasons: Addition of strong acid that is buffered by and consumes bicarbonate ion. Loss of bicarbonate ion from the body …
Bestpractice.bmj.comSymptoms, diagnosis and treatment - BMJ Best Practice
WEBJun 18, 2020 · The recommended dose of paracetamol is 4 g (or 75 mg/kg) in 24 hours for an adult patient. Any ingestion exceeding this is regarded as an overdose. However, toxicity is extremely unlikely if <75 mg/kg paracetamol has been ingested within a 24-hour period. Single acute overdose is defined as an ingestion of >4 g (or >75 mg/kg) in a period of <1
Bestpractice.bmj.comSymptoms, diagnosis and treatment - BMJ Best Practice
WEBJan 25, 2023 · An acute acetaminophen overdose in adults, in terms of FDA-labeled therapeutic dosing, is minimally defined as a cumulative dose of acetaminophen >4 g ingested over 8 hours or less (some authors use a period of 4 hours). [1] . Repeated supratherapeutic acetaminophen ingestion denotes ingestion of excess acetaminophen …
Bestpractice.bmj.comDengue fever - Symptoms, diagnosis and treatment - BMJ Best …
WEBMay 3, 2024 · Severe dengue fever is characterised by marked thrombocytopenia, severe haemorrhage, plasma leakage leading to shock or fluid accumulation with respiratory distress, and severe organ impairment. Confirmatory tests include viral antigen or nucleic acid detection and serology. Difficult to distinguish clinically from Zika and chikungunya …
Bestpractice.bmj.comEvaluation of metabolic acidosis - BMJ Best Practice
WEBAug 22, 2024 · Arterial pH <7.35 defines acidosis. Metabolic acidosis is indicated by a decrease in the plasma bicarbonate level and/or a marked increase in the serum anion gap (AG). Metabolic acidosis may occur due to the following reasons: Addition of strong acid that is buffered by and consumes bicarbonate ion. Loss of bicarbonate ion from the body …
Bestpractice.bmj.comSymptoms, diagnosis and treatment - BMJ Best Practice
WEBMar 20, 2024 · Ehlers-Danlos syndromes (EDS) are a group of inherited connective tissue disorders. [1] They are caused by pathogenic variants affecting genes encoding for, or modifying, collagen, fibrillin, and/or other matrix proteins. Ehlers-Danlos syndromes have similar phenotypes with varying degrees of expression that may include joint …
Bestpractice.bmj.com