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Comparison of published guidelines for management of …
WEBSep 16, 2020 — COVID-19-associated coagulopathy is well established in COVID-19 patients and is marked by a state of profound inflammation with endothelial dysfunction, abnormal flow dynamics, platelet activation, and hypercoagulability resulting in higher rates of thrombotic complications such as deep venous thrombosis (DVT), pulmonary embolism …
Ccforum.biomedcentral.comThe European guideline on management of major bleeding and …
WEBMar 1, 2023 — Background Severe trauma represents a major global public health burden and the management of post-traumatic bleeding continues to challenge healthcare systems around the world. Post-traumatic bleeding and associated traumatic coagulopathy remain leading causes of potentially preventable multiorgan failure and death if not diagnosed …
Ccforum.biomedcentral.comThe European guideline on management of major bleeding and …
WEBMar 27, 2019 — Background Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients. Now in its fifth edition, this document aims to provide guidance on the management of major bleeding and …
Ccforum.biomedcentral.comProthrombin complex concentrate (PCC) for treatment of trauma …
WEBNov 2, 2023 — Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing, and evidence to support its use in injured patients with hemorrhage are unclear. Methods A systematic search of …
Ccforum.biomedcentral.comManagement of bleeding and coagulopathy following major …
WEBApr 19, 2013 — The early acute coagulopathy associated with traumatic injury has recently been recognised as a multifactorial primary condition that results from a combination of bleeding-induced shock, tissue injury-related thrombin-thrombomodulin-complex generation and the activation of anticoagulant and fibrinolytic pathways (Figure 1) [5–7, 9–11].
Ccforum.biomedcentral.comThe unique characteristics of COVID-19 coagulopathy
WEBJun 18, 2020 — Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and …
Ccforum.biomedcentral.comThe European guideline on management of major bleeding and …
WEBApr 12, 2016 — Background Severe trauma continues to represent a global public health issue and mortality and morbidity in trauma patients remains substantial. A number of initiatives have aimed to provide guidance on the management of trauma patients. This document focuses on the management of major bleeding and coagulopathy following …
Ccforum.biomedcentral.comHypothermia and coagulation | Critical Care | Full Text - BioMed …
WEBJun 7, 2012 — The effects of hypothermia on coagulation may represent a two-edged sword in patients with acute brain injury who are treated with therapeutic cooling. On the one hand inhibition of coagulation can have positive effects, such as improvements in the microcirculation and inhibition of the formation of harmful microthrombi in the brain [1].
Ccforum.biomedcentral.comCoagulation phenotypes in sepsis and effects of recombinant …
WEBMar 19, 2021 — We examined the latent phenotypes of sepsis with coagulopathy and the associations between thrombomodulin treatment and the 28-day and in-hospital mortality for each phenotype. This was a secondary analysis of multicentre registries containing data on patients (aged ≥ 16years) who were admitted to intensive care units for severe …
Ccforum.biomedcentral.comHow I approach membrane lung dysfunction in patients receiving …
WEBNov 30, 2020 — Activation of coagulation and fibrinolysis can precipitate systemic coagulopathy or hemolysis, while clot deposition can obstruct blood flow [6, 7]. Additionally, moisture buildup in the gas phase and protein and cellular debris accumulation in the blood phase may contribute to shunt and dead-space physiology, respectively, impairing gas …
Ccforum.biomedcentral.com